Other Infectious Disease Areas

Herpes Simplex in Rodents

Filariasis in Rhesus Macaques

Chikungunya in Rodents and Macaques

Dengue in Rodents and Macaques

Representative Publications

Recombinant Protein Filovirus Vaccines Protect Cynomolgus Macaques From Ebola, Sudan, and Marburg Viruses.
Lehrer AT, Chuang E, Namekar M, Williams CA, Wong TAS, Lieberman MM, Granados A, Misamore J, Yalley-Ogunro J, Andersen H, Geisbert JB, Agans KN, Cross RW, Geisbert TW.
Front Immunol. 2021 Aug 18;12:703986. doi: 10.3389/fimmu.2021.703986. eCollection 2021.
PMID: 34484200 Free PMC article.

Single-vial filovirus glycoprotein vaccines: Biophysical characteristics and immunogenicity after co-lyophilization with adjuvant.
Preston KB, Wong TAS, To A, Tashiro TE, Lieberman MM, Granados A, Feliciano K, Harrison J, Yalley-Ogunro J, Elyard HA, Donini O, Lehrer AT, Randolph TW.
Vaccine. 2021 Sep 15;39(39):5650-5657. doi: 10.1016/j.vaccine.2021.08.003. Epub 2021 Aug 13.
PMID: 34400019

Passive Transfer of Vaccine-Elicited Antibodies Protects against SIV in Rhesus Macaques

Bioqual is proud to have been associated with the development of an effective vaccine against the Ebola virus recently licensed for use in humans by the European Commission

Darrah, P.A., Zeppa, J.J., Maiello, P. et al. Prevention of tuberculosis in macaques after intravenous BCG immunization. Nature 577, 95–102 (2020). http://doi.org/10.1038/s41586-019-1817-8

Dakshinamoorthy G, von Gegerfelt AAndersen HLewis M, Kalyanasundaram R. Evaluation of a  Multivalent Vaccine against Lymphatic Filariasis in Rhesus macaque Model. PLoS One. 2014 Nov 17;9(11):e112982. doi:10.1371/journal.pone.0112982. eCollection 2014. PubMed PMID: 25401783.

Akahata W, Yang ZY, Andersen H, Sun S, Holdaway HA, Kong WP, Lewis MG, Higgs S, Rossmann MG, Rao S, Nabel GJ. A virus-like particle vaccine for epidemic Chikungunya virus protects nonhuman primates against infection. Nat Med. 2010 Mar;16(3):334-8. doi: 10.1038/nm.2105. PubMed PMID: 20111039.

Mallilankaraman K, Shedlock DJ, Bao H, Kawalekar OU, Fagone P, Ramanathan AA, Ferraro B, Stabenow J, Vijayachari P, Sundaram SG, Muruganandam N, Sarangan G, Srikanth P, Khan AS, Lewis MG, Kim JJ, Sardesai NY, Muthumani K, Weiner DB. A DNA vaccine against chikungunya virus is protective in mice and induces neutralizing antibodies in mice and nonhuman primates. PLoS Negl Trop Dis. 2011 Jan 11;5(1):e928. doi: 10.1371/journal.pntd.0000928. PubMed PMID: 2126435.

McGee CE, Lewis MG, Claire MS, Wagner W, Lang J, Guy B, Tsetsarkin K, Higgs S, Decelle T. Recombinant chimeric virus with wild-type dengue 4 virus premembrane and envelope and virulent yellow fever virus Asibi backbone sequences is dramatically attenuated in nonhuman primates. J Infect Dis. 2008 Mar 1;197(5):693-7. doi: 10.1086/527329. PubMed PMID: 18266603.

Kenneth C. Bagley, Jennifer A. Schwartz, Hanne Andersen, John H. Eldridge, Rong Xu, Ayuko Ota-Setlik, Joshua J. Geltz, William P. Halford, and Timothy R. Fouts. An IL-12 Adjuvanted HSV-2 DNA Vaccine is More Protective than a Glycoprotein D Subunit Vaccine in a High-Dose Murine Challenge Model. Viral Immunology. In Press.