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influenza

Influenza

Animal Models

  • BALB/c mice
  • Ferrets
  • Various NHPs

Study Types

  • Vaccine testing
  • Therapeutics testing
  • PK/safety testing
  •  Dose-ranging studies
  • Transfusions
  • ABSL-3 (including Select Agent) and enhanced BSL-2 requiring studies

In vitro Services

  • Virus stock generation in embryonated chicken eggs
  • Various H1N1, H2N2, H3N2, H5N1, H7N3, H7N7, H7N9, H9N2 and B virus strains available
  • Sample processing
  • ELISA, HAI and MN assays
  • Infectious and QT-PCR viral load testing
  • Ferret cytokine/chemokine mRNA levels

Representative Publications

Masaru Kanekiyo, M. Gordon Joyce, Rebecca A. Gillespie, John R. Gallagher, Sarah F. Andrews, Hadi M. Yassine, Adam K. Wheatley, Brian E. Fisher, David R. Ambrozak, Adrian Creanga, Kwanyee Leung, Eun Sung Yang, Seyhan Boyoglu-Barnum, Ivelin S. Georgiev, Yaroslav Tsybovsky, Madhu S. Prabhakaran, Hanne Andersen, Wing-Pui Kong, Ulrich Baxa, Kathryn L. Zephir, Julie E. Ledgerwood, Richard A. Koup, Peter D. Kwong, Audray K. Harris, Adrian B. McDermott, John R. Mascola & Barney S. Graham. Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses. Nature Immunology, volume 20, pages 362–372 (2019).

DiNapoli, J. M., Nayak, B., Yang L., Finneyfrock B.W., Cook A., Andersen H., Torres-Velez F., Murphy B., Samal S. K., Collins P. L., and Bukreyev A. Newcastle disease virus-vectored Vaccines expressing the hemagglutinin or neuraminidase protein of H5N1 highly pathogenic avian influenza virus protect against virus challenge in monkeys. J. Virol. 2009 Nov. 18

Wei CJ, Boyington JC, McTamney PM, Kong WP, Pearce MB, Xu L, Andersen H, Rao S, Tumpey TM, Yang ZY, Nabel GJ. Induction of Broadly Neutralizing H1N1 Influenza Antibodies by Vaccination. Science. 2010 Jul 15. PMID: 20647428.

Yassine HM, Boyington JC, McTamney PM, Wei C-J, Kanekiyo M, Kong W-P, Gallagher JR, Wang L, Zhang Y, Joyce MG, Lingwood D, Moin SM, Andersen H, Okuno Y, Rao SS, Harris AK, Kwong PD, Mascola JR, Nabel GJ, and BS Graham. Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection. Nature Medicine (2015). 24 August. doi:10.1038/nm.3927.