COVID-19

Animal Models

  • Golden Syrian hamsters
  • BALB/c mice
  • hACE2 tg mice
  • Ferrets
  • AGM, rhesus and cynomolgus macaques

Study Types

  • Vaccine testing
  • Therapeutics testing
  • PK/safety testing
  • Pathogenesis

In vitro Services

  • Sample processing
  • qRT-PCR, TCID50 and plaque assay viral load testing
  • Binding antibody ELISA and PRNT
  • SARS-CoV-2 and SARS-CoV stock generation
  • Cytokine/chemokine detection by Luminex and ELISA

Representative Publications

Mucosal adenovirus vaccine boosting elicits IgA and durably prevents XBB.1.16 infection in nonhuman primates
Gagne M, Flynn BJ, Andrew SF, Marquez J, Flebbe DR, Mychalowych A, Lamb E, Davis-Gardner ME, Burnett MR, Serebryannyy LA, Lin BC, Ziff ZE, Maule E, Carroll R, Naisan M, Jethmalani Y, Pessaint L, Todd JM, Doria-Rose NA, Case JB, Dmitriev IP, Kashentseva EA, Ying B, Dodson A, Kouneski K, O’Dell S, Wali B, Ellis M, Godbole S, Laboune F, Henry AR, Teng IT, Wang D, Wang L, Zhou Q, Zouantchangadou S, Van Ry A, Lewis MG, Andersen H, Kwong PD, Curiel DT, Roederer M, Nason MC, Foulds KE, Suthar MS, Diamond MS, Douek DC, Seder RA.
Nat Immunol. 2024 Sep 3. doi: 10.1038/s41590-024-01951-5. Online ahead of print.
PMID: 39227514

Variant-proof high affinity ACE2 antagonist limits SARS-CoV-2 replication in upper and lower airways
Balachandran H, Kroll K, Terry K, Manickam C, Jones R, Woolley G, Hayes T, Martinot AJ, Sharma A, Lewis M, Jost S, Reeves RK.
PLoS Pathog. 2024 Aug 12;20(8):e1012439. doi: 10.1371/journal.ppat.1012439. Online ahead of print.
PMID: 39133756

NK cells modulate in vivo control of SARS-CoV-2 replication and suppression of lung damage
Gagne M, Flynn BJ, Honeycutt CC, Flebbe DR, Andrew SF, Provost SJ, McCormick L, Van Ry A, McCarthy E, Todd JM, Bao S, Teng IT, Marciano S, Rudich Y, Li C, Jain S, Wali B, Pessaint L, Dodson A, Cook A, Lewis MG, Andersen H, Zahradník J, Suthar MS, Nason MC, Foulds KE, Kwong PD, Roederer M, Schreiber G, Seder RA, Douek DC.
Nat Commun. 2024 Aug 12;15(1):6894. doi: 10.1038/s41467-024-51046-w.
PMID: 39134521

Broadly neutralizing antibody induction by non-stabilized SARS-CoV-2 Spike mRNA vaccination in nonhuman primates

Mucosal boosting enhances vaccine protection against SARS-CoV-2 in macaques

Ad26.COV2.S and SARS-CoV-2 spike protein ferritin nanoparticle vaccine protect against SARS-CoV-2 Omicron BA.5 challenge in macaques

Correlates of protection against SARS-CoV-2 in rhesus macaques

A Single Immunization with Nucleoside-Modified mRNA Vaccines Elicits Strong Cellular and Humoral Immune Responses against SARS-CoV-2 in Mice

REGN-COV2 Antibodies Prevent and Treat SARS-CoV-2 Infection in Rhesus Macaques and Hamsters

Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters

Potently neutralizing and protective human antibodies against SARS-CoV-2

SARS-CoV-2 infection protects against rechallenge in rhesus macaques

DNA vaccine protection against SARS-CoV-2 in rhesus macaques

BIOQUAL involved in the fight against COVID-19