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zika2

Zika

Animal Models

  • BALB/c, A129 and AG129 mice
  • Rhesus and cynomolgus macaques
  • Pregnant macaques

Study Types

  • Vaccine testing
  • Therapeutics testing
  • PK/safety testing
  • Pathogenesis

In vitro Services

  • Sample processing
  • QT-PCR viral load testing
  • Binding antibody ELISA and PRNT
  • Flow-based characterization of PBMC populations
  • Functional T cell assays

Representative Publications

Dowd, KA, Sung-Youl Ko, Kaitlyn M. Morabito, Eun Sung Yang, Rebecca S. Pelc, Christina R. DeMaso, Leda R. Castilho, Peter Abbink, Michael Boyd, RamyaNityanandam, David N. Gordon, John Gallagher, Xuejun Chen, John-Paul Todd, YaroslavTsybovsky, Audray Harris, Yan-Jang S. Huang, Stephen Higgs, Dana L. Vanlandingham, Hanne Andersen, Mark G. Lewis, Rafael De La Barrera, Kenneth H. Eckels, Richard G. Jarman, Martha C. Nason, Dan H. Barouch, Mario Roederer, Wing-Pui Kong, John R. Mascola, Theodore C. Pierson, Barney S. Graham. Rapid Development of a Zika Virus Vaccine. Science 2016; September 22.10.1126/Science.aai3197.

Osuna, CE, So-Yon Lim, Jacob D. Estes, Claire Deleage, Erwing Fabian Cardozo Ojeda, Lucas Schroeder, Katharine Best, Ma Lou, Peter T. Hraber, Hanne Andersen Elyard, Scott Huang, Stephen Higgs, Alan Perelson, David Safronetz, Mark G. Lewis and James B. Whitney. Viral Dynamics and Shedding in Zika Virus Infected Macaques. Nature Medicine. October 3, 2016. DOI: 10.1038/nm.4206.

Abbink P, Larocca RA, De La Barrera RA, Bricault CA, Moseley ET, Boyd M, Kirilova M, Li Z, Ng'ang'a D, Nanayakkara O, Nityanandam R, Mercado NB, Borducchi EN, Agarwal A, Brinkman AL, Cabral C, Chandrashekar A, Giglio PB, Jetton D, Jimenez J, Lee BC, Mojta S, Molloy K, Shetty M, Neubauer GH, Stephenson KE, Peron JP, Zanotto PM, Misamore J, Finneyfrock B, Lewis MG, Alter G, Modjarrad K, Jarman RG, Eckels KH, Michael NL, Thomas SJ, Barouch DH. Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys. Science. 2016 Sep 9;353(6304):1129-32. doi: 10.1126/science.aah6157. PubMed PMID: 27492477.