Contract Services

CURRENTLY AVAILABLE

• Progestational/Anti-progestational Activity - McPhail and McGinty Assays (Immature female rabbits)
• Androgenic/Myotropic and Anti-Androgenic/Anti-Myotropic Activity - Hershberger Assay or Duration of Activity Assay (Immature castrated male rats)
• Estrogenic/Anti-Estrogenic Activity - Uterotropic (Immature female rats), Vaginal Cornification/Uterotrophic (Adult ovariectomized rats), and Uterine Withdrawal Bleeding (Adult ovariectomized monkeys)
• Glucocorticoid/Anti-Glucocorticoid Activity - Thymolytic Assay (Adrenalectomized 125-150 g male rats) and Stimulation of Cortisol Secretion (Intact female monkey)
• Ovulatory/Anti-Ovulatory Activity (4-day cyclic rats)
• Estrous Cycle Suppression (4- or 5-day cyclic rats)
• Antifertility Activity - Postcoital (Time-mated female rats and rabbits), Spermicidal Intravaginal Administration (Time-mated rabbits), Fertility Suppression (Mated adult male and female rats and rabbits), and Testicular Morphological Assessments (rats)
• Steroid Hormone Receptor Assays (AR, ER, ERα, ERß, PR, PRα, PRß and GR: human, rabbit, rat)
• Cell Culture Based Assays to Assess Agonist/Antagonist Activity of CDB Compounds - Alkaline Phosphatase Production in T47D-CO Human Breast Cancer Cells (progestin agonist/antagonist activity); Stimulation or Inhibition of Transcriptional Activation (transient transfections) in Cell Lines (agonist/antagonist activity for androgen, estrogen, progestin, or glucocorticoid activity); Stimulation or Inhibition of PSA Production by CWR22Rv1 Prostate Cancer Cells (androgen agonist/antagonist activity)
• Cytotoxiciy Assays in Cancer Cell Lines In Vitro or In Vivo -Stimulation or Inhibition of Growth of Breast or Prostate Cancer Cell Lines In Vitro Using Cell Viability (MTS assay), ATP Levels, LDH (toxicity), or Caspase 3/7 (apoptosis) as endpoints: Anti-tumorigenic Activity in Breast or Prostate Cancer Xenografts in Nude Mice
• Two-week Rabbit Hepatotoxicity Assay: BSP Dye Retention and Serum Biomarker Enzyme Levels
• Antisera Production/Titration/Specificity Testing (Adult male rabbits)
• Radioimmunoassays and ELISA’s - Steroid Hormones, Gonadotropins, Steroidal Contraceptives, Prolactin, Inhibin B, and Prostate Specific Antigen (Humans, monkeys, rabbits, and rodents as applicable)
• Gonadotropin and Steroid Hormone Stimulation or Suppression Assays (Monkeys, rabbits, and rodents)
• In Vitro Histamine Release From Peritoneal Mast Cells - (Adult male or female rats)
• Vaginal pH/Irritation Assay (Adult female rabbits)
• Short-term In Vivo Toxicity Assays (Rats and mice)
• Bioavailability/Pharmacokinetics Studies (Monkeys, rabbits, and rodents)
• Albumin Production
• Cell Line Cytosol Binding Assay
• Isolation of Sertoli Cells
• GLP Assays
• Cost of each assay depends on the experimental design including the number of treatment groups and number of animals employed.